Can Biologists Rewrite the Genome’s Spaghetti Code?
In an interview, author Adrian Woolfson discusses his concept of artificial biological intelligence (ABI), arguing that AI and DNA synthesis are enabling a new engineering paradigm for biology. He explains the challenge of genomes being 'spaghetti code' shaped by evolution, and how researchers are refactoring genomes, such as the Sc2.0 synthetic yeast project. Woolfson highlights AI tools like genome language models and DNA synthesis technologies that could turn DNA into a programmable material, but warns of risks including ecological disruption and misuse.
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