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[Submitted on 10 Sep 2026] Title:A Physics-Based Closed-Loop Robotic Bioprinting Framework Towards Volumetric Muscle Loss Treatment View a PDF of the paper titled A Physics-Based Closed-Loop Robotic Bioprinting Framework Towards Volumetric Muscle Loss Treatment, by Omid Rezayof and 7 other authors View PDF HTML (experimental) Abstract:Robotic bioprinting and Direct Ink Writing (DIW) are being explored towards the treatment of Volumetric Muscle Loss (VML). While previous studies have shown the importance of proper parameter selection on the print outcome, existing approaches often rely on time- and material-intensive design of experiments methods, or require large, well-curated datasets for training machine learning models. In this paper, we propose a physics-based closed-loop robotic bioprinting system capable of near real-time parameter adaptation. The system integrates a 3D point cloud camera and fully autonomous vision-based algorithms to provide quantitative evaluation of printed constructs. This evaluation is fed into a controller that adjusts printing parameters to achieve a desired bead thickness. To assess the framework's performance, four experimental configurations were tested, each repeated three times. In these tests, printing began from an arbitrary initial parameter value, and the controller was tasked with adjusting the parameters to reach the desired thickness. The system converged in all trials, achieving a tracking error below 0.5 mm within an average of 5.2 seconds from the start of printing. The low standard deviation of the converged pressure over different tests (0.04 bar on average) demonstrates robustness and repeatability. Additional experiments were conducted with the controller turned off, enabling direct comparison with open-loop DIW bioprinting, further confirming the effectiveness of the proposed closed-loop framework in achieving the desired bead geometry. Comments: This paper has been accepted for publication and presentation in 2026 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2026) Subjects: Robotics (cs.RO) Cite as: arXiv:2609.12159 [cs.RO] (or arXiv:2609.12159v1 [cs.RO] for this version) https://doi.org/10.48550/arXiv.2609.12159 arXiv-issued DOI via DataCite (pending registration) Submission history From: Omid Rezayof [view email] [v1] Thu, 10 Sep 2026 19:44:51 UTC (1,411 KB) Full-text links: Access Paper: View a PDF of the paper titled A Physics-Based Closed-Loop Robotic Bioprinting Framework Towards Volumetric Muscle Loss Treatment, by Omid Rezayof and 7 other authors View PDF HTML (experimental) TeX Source view license Current browse context: cs.RO new | recent | 2026-09 Change to browse by: cs References & Citations NASA ADS Google Scholar Semantic Scholar Loading... Data provided by: Bibliographic Tools Bibliographic and Citation Tools Bibliographic Explorer Toggle Bibliographic Explorer (What is the Explorer?) Connected Papers Toggle Connected Papers (What is Connected Papers?) Litmaps Toggle Litmaps (What is Litmaps?) scite.ai Toggle scite Smart Citations (What are Smart Citations?) Code, Data, Media Code, Data and Media Associated with this Article alphaXiv Toggle alphaXiv (What is alphaXiv?) Links to Code Toggle CatalyzeX Code Finder for Papers (What is CatalyzeX?) DagsHub Toggle DagsHub (What is DagsHub?) GotitPub Toggle Gotit.pub (What is GotitPub?) Huggingface Toggle Hugging Face (What is Huggingface?) ScienceCast Toggle ScienceCast (What is ScienceCast?) Demos Demos Replicate Toggle Replicate (What is Replicate?) Spaces Toggle Hugging Face Spaces (What is Spaces?) Spaces Toggle TXYZ.AI (What is TXYZ.AI?) Related Papers Recommenders and Search Tools Link to Influence Flower Influence Flower (What are Influence Flowers?) Core recommender toggle CORE Recommender (What is CORE?) Author Venue Institution Topic About arXivLabs arXivLabs: experimental projects with community collaborators arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs. Which authors of this paper are endorsers? | Disable MathJax (What is MathJax?)