Interpretable machine learning predicts Parkinson's disease severity using motion-corrected QSM MRI and multiband multiecho fMRI features

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[Submitted on 26 Jun 2026]

Title:Interpretable machine learning predicts Parkinson's disease severity using motion-corrected QSM MRI and multiband multiecho fMRI features

View a PDF of the paper titled Interpretable machine learning predicts Parkinson's disease severity using motion-corrected QSM MRI and multiband multiecho fMRI features, by Aixa X. Andrade

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Abstract:Introduction: Objective neuroimaging biomarkers may improve Parkinson's disease motor assessment by capturing brain variation not directly observable from clinical examination. We used interpretable machine learning to predict current motor severity, measured by MDS-UPDRS Part III, from QSM and multiband multi-echo resting-state fMRI-derived ReHo features.

Methods: Regional QSM and ReHo features were extracted from 28 participants, including 24 individuals with Parkinson's disease and 4 controls. Thirteen feature-set experiments evaluated imaging-only, clinical-only, imaging-plus-clinical, full, reduced, and multimodal inputs. Support vector regression, Elastic Net, Random Forest, and XGBoost models were trained using nested cross-validation. Performance was assessed using pooled held-out R^2, RMSE, MAE, Pearson correlation, permutation testing, and the proportion of participants predicted within +/-5 MDS-UPDRS Part III points.

Results: Imaging-only models carried meaningful predictive signal, whereas the clinical-only model performed weakly. Full fMRI, full QSM, and clinical variables provided the strongest global fit, explaining 45.4% of variance in motor severity. Selected QSM plus clinical variables produced the most clinically close predictions, with 75.0% of participants predicted within +/-5 points and the lowest MAE among top-performing models. SHAP highlighted cerebellar, thalamic, striatal, insular, and motor cortical features.

Conclusion: QSM and multiband multi-echo fMRI-derived ReHo capture distinct, interpretable dimensions of Parkinson's disease motor severity. These findings show that structural and functional imaging contribute differently depending on the clinical prediction goal.

Comments: 16 pages from main manuscript and 17 pages from supplementary information

Subjects:

Computer Vision and Pattern Recognition (cs.CV); Machine Learning (cs.LG); Neurons and Cognition (q-bio.NC)

Cite as: arXiv:2607.02553 [cs.CV]

(or arXiv:2607.02553v1 [cs.CV] for this version)

https://doi.org/10.48550/arXiv.2607.02553

arXiv-issued DOI via DataCite

Submission history

From: Aixa X. Andrade [view email] [v1] Fri, 26 Jun 2026 20:26:37 UTC (6,847 KB)

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