Insilico Medicine advances AI drug for IPF to Phase III trials

Insilico Medicine is advancing to Phase III human trials for testing a drug identified by AI targeting idiopathic pulmonary fibrosis (IPF). This progression supplies the computational drug discovery sector with empirical test cases, advancing an AI medicine past early safety evaluations into late-stage efficacy validation. IPF destroys respiratory capacity through severe lung tissue scarring. Patients typically present a median survival rate reaching two to four years post-diagnosis. The AI-identified drug, rentosertib, inhibits the TRAF2- and NCK-interacting kinase to address underlying disease mechanisms when administered orally. A randomised trial evaluated 71 patients across 22 Chinese clinical sites, separating participants into placebo and active treatment cohorts. Investigators adm…