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Zero-Shot Respiratory Sound Classification through LLM-Augmented Audio-Text Alignment

Summary

Self-supervised respiratory encoders lack clinical semantic grounding for zero-shot inference. This research proposes a framework aligning these encoders with medical terminology in a shared latent space, turning them into zero-shot-capable foundation models. Using a medical LLM to synthesize structured reports from metadata addresses data scarcity. Across 9 tasks on 6 datasets, the method achieves a 61.3% mean zero-shot AUC, surpassing CLAP (51.4%) and Qwen2-Audio (54.9%), and reaches the highest linear probing AUC (71.6%) with only 43% of data used by full-scale baselines.

SourcearXiv Computational LinguisticsAuthor: Mustafa Talha \.Ilerisoy, Hung Manh Pham, Mathias Funk, Mykola Pechenizkiy, Aaqib Saeed
Zero-Shot Respiratory Sound Classification through LLM-Augmented Audio-Text Alignment
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[Submitted on 30 Aug 2026]

Title:Zero-Shot Respiratory Sound Classification through LLM-Augmented Audio-Text Alignment

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Abstract:Self-supervised respiratory encoders lack semantic grounding in clinical domain needed for zero-shot inference, limiting their utility without task-specific labeled data. We propose a framework that aligns these encoders with medical terminology in a shared latent space turning them into a zero-shot-capable foundation model. To address paired data scarcity, we use a medical LLM to synthesize structured reports from metadata, creating dense semantic anchors for contrastive learning. Our training combines a sigmoid-based contrastive loss with encoder's native SSL objective and similarity-aware negative sampling to sharpen pathological boundaries. Across 9 tasks on 6 datasets, our method achieves a 61.3% mean zero-shot AUC, surpassing CLAP (51.4%) and Qwen2-Audio (54.9%) while reaching the highest linear probing AUC (71.6%) with only 43% of data used by full-scale baselines, showing that structured semantic alignment outperforms large-scale, general-purpose models in clinical diagnostics.

Comments: Accepted to INTERSPEECH 2026

Subjects:

Computation and Language (cs.CL); Artificial Intelligence (cs.AI); Sound (cs.SD)

Cite as: arXiv:2609.00055 [cs.CL]

(or arXiv:2609.00055v1 [cs.CL] for this version)

https://doi.org/10.48550/arXiv.2609.00055

arXiv-issued DOI via DataCite

Submission history

From: Mustafa Talha İlerisoy [view email] [v1] Sun, 30 Aug 2026 11:49:54 UTC (136 KB)

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Key points

  • Proposes a framework aligning self-supervised respiratory encoders with clinical semantics for zero-shot classification.
  • Uses a medical LLM to synthesize structured reports, mitigating paired data scarcity.
  • Achieves 61.3% mean zero-shot AUC over 9 tasks on 6 datasets, outperforming CLAP and Qwen2-Audio.
  • Reaches highest linear probing AUC (71.6%) using only 43% of full-scale baseline data.

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