[Submitted on 16 May 2026]
Title:Reverse Item Response Theory for Sparsity-Robust Ranking in Fragmented Cancer Drug-Response Matrices
View a PDF of the paper titled Reverse Item Response Theory for Sparsity-Robust Ranking in Fragmented Cancer Drug-Response Matrices, by Jung Min Kang
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Abstract:We introduce reverse Item Response Theory (IRT) to pharmacogenomic drug-response analysis by treating cancer types as latent "subjects" with resistance ability and drugs as "items" with evasion difficulty. Applied to 242,036 drug sensitivity measurements from the Genomics of Drug Sensitivity in Cancer (GDSC2) database, the model estimates cancer-type-level in-vitro resistance and drug-level broad activity on a shared latent scale. Validation across four missingness regimes demonstrates that reverse IRT better recovers the full-data latent ranking than simple averaging, with advantages of Delta-rho = +0.089 to +0.095 at 60% missingness under MCAR, cancer-biased, and drug-biased sparsity. Held-out prediction confirms IRT achieves the best Brier score among five evaluated methods. Bootstrap confidence intervals show 19 of 28 cancer types have stable resistant/sensitive classifications. Cross-platform PRISM replication shows 82% directional agreement but weak rank-order correlation (rho = 0.25), indicating the contribution is methodological robustness under fragmented evaluation, not a universal clinical resistance leaderboard.
Comments: 8 pages, 4 figures, 3 tables
Subjects:
Machine Learning (cs.LG)
Cite as: arXiv:2610.00002 [cs.LG]
(or arXiv:2610.00002v1 [cs.LG] for this version)
https://doi.org/10.48550/arXiv.2610.00002
arXiv-issued DOI via DataCite
Submission history
From: Jung Min Kang [view email] [v1] Sat, 16 May 2026 17:28:31 UTC (63 KB)
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