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[Submitted on 2 Oct 2026] Title:RadOnc-Agent: An LLM-Orchestrated Framework for AI Workflows Across the Radiotherapy Care Pathway View a PDF of the paper titled RadOnc-Agent: An LLM-Orchestrated Framework for AI Workflows Across the Radiotherapy Care Pathway, by Caiwen Jiang and 5 other authors View PDF HTML (experimental) Abstract:Artificial intelligence has advanced individual radiotherapy tasks, yet these capabilities remain separated across clinical stages, software environments and data modalities. This fragmentation contrasts with the longitudinal radiotherapy workflow from treatment decision-making through follow-up. Here we present RadOnc-Agent, an agentic artificial-intelligence framework that formalizes radiotherapy into four clinical phases and provides 26 callable functions through a conversational interface. A large-language-model controller maps clinical intent to schema-constrained calls, preserves patient and workflow context, and routes requests to specialist services. We evaluated system execution using 2,600 single-function requests (7,800 repeat executions), 200 prespecified synthetic cross-stage scenarios spanning four phases (600 executions), and 120 workflow instances from 60 de-identified patient records (360 clean executions) representing decision-to-planning and planning-to-adaptation. RadOnc-Agent selected the intended function in 98.79% of single-function executions, completed 96.50% of scripted cross-stage workflows, and completed 96.67% of real-patient workflow executions. In comparative ablations, removing longitudinal state reduced cross-stage completion from 96.50% to 84.00%, while disabling schema and identity validation increased mismatched backend dispatch from 0% to 95.28% in a replay/test evaluation. These findings establish the technical feasibility of an LLM-orchestrated architecture for coordinating heterogeneous radiotherapy capabilities and information across longitudinal workflows; they do not establish clinical correctness, clinical utility or prospective benefit. Subjects: Artificial Intelligence (cs.AI) Cite as: arXiv:2610.06923 [cs.AI] (or arXiv:2610.06923v1 [cs.AI] for this version) https://doi.org/10.48550/arXiv.2610.06923 arXiv-issued DOI via DataCite (pending registration) Submission history From: Caiwen Jiang [view email] [v1] Fri, 2 Oct 2026 22:39:48 UTC (29,623 KB) Full-text links: Access Paper: View a PDF of the paper titled RadOnc-Agent: An LLM-Orchestrated Framework for AI Workflows Across the Radiotherapy Care Pathway, by Caiwen Jiang and 5 other authors View PDF HTML (experimental) TeX Source view license Additional Features Audio Summary Current browse context: cs.AI new | recent | 2026-10 Change to browse by: cs References & Citations NASA ADS Google Scholar Semantic Scholar Loading... Data provided by: Bibliographic Tools Bibliographic and Citation Tools Bibliographic Explorer Toggle Bibliographic Explorer (What is the Explorer?) Connected Papers Toggle Connected Papers (What is Connected Papers?) Litmaps Toggle Litmaps (What is Litmaps?) scite.ai Toggle scite Smart Citations (What are Smart Citations?) Code, Data, Media Code, Data and Media Associated with this Article alphaXiv Toggle alphaXiv (What is alphaXiv?) Links to Code Toggle CatalyzeX Code Finder for Papers (What is CatalyzeX?) DagsHub Toggle DagsHub (What is DagsHub?) GotitPub Toggle Gotit.pub (What is GotitPub?) Huggingface Toggle Hugging Face (What is Huggingface?) ScienceCast Toggle ScienceCast (What is ScienceCast?) Demos Demos Replicate Toggle Replicate (What is Replicate?) Spaces Toggle Hugging Face Spaces (What is Spaces?) Spaces Toggle TXYZ.AI (What is TXYZ.AI?) Related Papers Recommenders and Search Tools Link to Influence Flower Influence Flower (What are Influence Flowers?) Core recommender toggle CORE Recommender (What is CORE?) Author Venue Institution Topic About arXivLabs arXivLabs: experimental projects with community collaborators arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs. Which authors of this paper are endorsers? | Disable MathJax (What is MathJax?)