[Submitted on 25 Jun 2026]
Title:HantaWatch: Federated Learning for Hantavirus Genomic Surveillance
View a PDF of the paper titled HantaWatch: Federated Learning for Hantavirus Genomic Surveillance, by Shanika Iroshi Nanayakkara and Shiva Raj Pokhrel
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Abstract:Hantavirus genomic surveillance is limited by the distribution of sequence data, non-IID source heterogeneity, and constrained expert-review capacity. We propose HantaWatch, a federated learning framework that enables laboratories and surveillance sites to collaboratively train sequence-based models without sharing raw data. HantaWatch integrates k-mer feature extraction, source-aware federated client construction, adaptive DU-FedProx optimization, surveillance-specific model selection, and prediction-only triage. Experiments on binary and multi-class tasks show that HantaWatch supports high-risk screening, outbreak-associated prediction, clade classification, and clinical-syndrome categorization while balancing predictive performance, false-negative risk, and update stability. The framework converts model output into risk scores, confidence estimates, uncertainty flags, and ranked expert-review priorities. HantaWatch therefore provides a practical federated decision-support layer for decentralized Hantavirus surveillance, supporting expert prioritization without replacing laboratory or public-health interpretation.
Subjects:
Machine Learning (cs.LG); Artificial Intelligence (cs.AI)
Cite as: arXiv:2607.16234 [cs.LG]
(or arXiv:2607.16234v1 [cs.LG] for this version)
https://doi.org/10.48550/arXiv.2607.16234
arXiv-issued DOI via DataCite
Submission history
From: S Nanayakkara [view email] [v1] Thu, 25 Jun 2026 04:22:00 UTC (7,729 KB)
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