Graph Mamba Survival Analysis Based on Topology-Aware Ordering
The paper proposes TopoMamSurv, a novel framework for whole slide image survival analysis that addresses Transformer's computational bottleneck and Mamba's sensitivity to input order. Using topology-aware ordering, bidirectional Mamba module, and GCN integration, it achieves efficient long-range dependency modeling and spatial structure utilization. Validated on five TCGA datasets.
[2606.02602] Graph Mamba Survival Analysis Based on Topology-Aware ordering
[Submitted on 23 May 2026]
Title:Graph Mamba Survival Analysis Based on Topology-Aware ordering
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Abstract:In computational pathology, Whole Slide Images (WSIs) survival analysis is crucial for patient prognosis assessment, but it faces multiple technical challenges. Although the Transformer captures long-range dependencies through its self-attention mechanism, its $O(N^2)$ time complexity causes a severe computational bottleneck in large-scale WSIs graph structures. The Mamba model breaks through the Transformer's computational bottleneck with linear complexity. But, owing to Mamba's high sensitivity to the order of input data, traditional node sorting methods in Graph Mamba, such as those based on node degree or subgraph size, fail to adequately account for the topological connectivity of graph data. This inadequacy consequently restricts the performance of Mamba's sequential modeling. Moreover, its unidirectional architecture cannot leverage the bidirectional spatial structure of images. To address these challenges, this paper proposes a novel Graph Mamba survival analysis framework based on topology-aware ordering (TopoMamSurv) to adapt to the sequential sensitivity of Mamba. Our visualization experiments further confirmed that the nodes extracted through the topology-aware ordering (TAO) strategy indeed exhibit higher similarity. Furthermore, we designed a bidirectional Mamba module and integrated a Graph Convolutional Network (GCN) to achieve bidirectional spatial context modeling of images, forming a hierarchical feature learning architecture for "local aggregation - global capture." This framework effectively reconciles the contradiction between long-range dependency modeling, computational efficiency, and spatial structure utilization in WSIs analysis through its systematic design of TAO, bidirectional semantic modeling, and hierarchical feature fusion. This framework has been validated for its comprehensive performance advantage on five TCGA datasets.
Subjects:
Machine Learning (cs.LG); Computer Vision and Pattern Recognition (cs.CV)
Cite as: arXiv:2606.02602 [cs.LG]
(or arXiv:2606.02602v1 [cs.LG] for this version)
https://doi.org/10.48550/arXiv.2606.02602
arXiv-issued DOI via DataCite
Submission history
From: Yuanfang Chen [view email] [v1] Sat, 23 May 2026 09:23:12 UTC (1,328 KB)
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