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Disentangled Learning Improves Implicit Neural Representations for Medical Reconstruction

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Implicit neural representations (INRs) have emerged as a powerful paradigm for medical imaging via physics-informed unsupervised learning. Classical INRs optimize an entire network from scratch for each subject, leading to inefficient training and suboptimal imaging quality. Recent initialization-based approaches attempt to inject population priors into pre-trained networks, yet they rely on high-quality images and often suffer from catastrophic forgetting during fine-tuning. We present DisINR, a novel INR framework that explicitly disentangles shared and subject-specific representations. DisINR introduces a shared encoder-decoder pair and subject-specific encoders, whose features are jointly decoded for image reconstruction. By integrating differentiable forward models, it pre-trains the…

SourcearXiv Computer VisionAuthor: Qing Wu, Xuanyu Tian, Chenhe Du, Haonan Zhang, Xiao Wang, Le Lu, Yuyao Zhang
Disentangled Learning Improves Implicit Neural Representations for Medical Reconstruction
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[2605.04234] Disentangled Learning Improves Implicit Neural Representations for Medical Reconstruction

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arXiv:2605.04234 (cs)

[Submitted on 5 May 2026]

Title:Disentangled Learning Improves Implicit Neural Representations for Medical Reconstruction

Authors:Qing Wu, Xuanyu Tian, Chenhe Du, Haonan Zhang, Xiao Wang, Le Lu, Yuyao Zhang

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Abstract:Implicit neural representations (INRs) have emerged as a powerful paradigm for medical imaging via physics-informed unsupervised learning. Classical INRs optimize an entire network from scratch for each subject, leading to inefficient training and suboptimal imaging quality. Recent initialization-based approaches attempt to inject population priors into pre-trained networks, yet they rely on high-quality images and often suffer from catastrophic forgetting during fine-tuning. We present DisINR, a novel INR framework that explicitly disentangles shared and subject-specific representations. DisINR introduces a shared encoder-decoder pair and subject-specific encoders, whose features are jointly decoded for image reconstruction. By integrating differentiable forward models, it pre-trains the shared modules directly from limited raw measurements, removing the need for pre-acquired high-quality images. During test-time adaptation, only the subject-specific encoder is optimized, while the shared pair remains frozen, effectively preserving learned priors. Extensive evaluations on three representative medical imaging tasks show that DisINR significantly outperforms state-of-the-art INRs in both reconstruction accuracy and efficiency.

Comments: 17 pages

Subjects:

Computer Vision and Pattern Recognition (cs.CV)

Cite as: arXiv:2605.04234 [cs.CV]

(or arXiv:2605.04234v1 [cs.CV] for this version)

https://doi.org/10.48550/arXiv.2605.04234

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arXiv-issued DOI via DataCite (pending registration)

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From: Qing Wu [view email] [v1] Tue, 5 May 2026 19:21:02 UTC (13,397 KB)

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Key points

  • DisINR disentangles shared and subject-specific representations, improving reconstruction quality and efficiency.
  • Pre-trains shared modules from raw measurements using differentiable forward models, avoiding reliance on high-quality images.
  • Only updates subject-specific encoders at test time, preventing catastrophic forgetting.
  • Outperforms existing methods across multiple medical imaging tasks.

Highlights and analysis are generated automatically and may contain errors. Check the original source.