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DINOv3-MIL: Per-Kidney Multi-Label Tumour and Cyst Detection from Foundation-Model Patch Tokens on KiTS23

Summary

Foundation vision models trained on natural images can be applied to medical tasks without domain-specific pre-training. This study compares three aggregators for renal tumour and cyst detection using DINOv3 features on KiTS23, finding that gated attention multiple instance learning (MIL) achieves the best performance, with AUROC of 0.74 for tumour and 0.80 for cyst. The prototype head fails on cyst detection, highlighting a trade-off between interpretability and performance.

SourcearXiv Computer VisionAuthor: Vishalakshi M, Sahil Sharma, Pramod Kumar P
DINOv3-MIL: Per-Kidney Multi-Label Tumour and Cyst Detection from Foundation-Model Patch Tokens on KiTS23
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[Submitted on 16 Jul 2026]

Title:DINOv3-MIL: Per-Kidney Multi-Label Tumour and Cyst Detection from Foundation-Model Patch Tokens on KiTS23

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Abstract:Foundation vision models trained on natural images transfer to medical tasks without domain pre-training, but volumetric classification requires aggregating tens of thousands of patch tokens per study, and the aggregator constrains how the resulting model can be interpreted. We compare three aggregators on identical frozen DINOv3 ViT-H/16+ features for renal tumour/cyst detection on KiTS23 (966 kidneys; n=97 test): a CLS-token linear probe, gated attention multiple instance learning (MIL) over 55,296 patch tokens, and a prototype head following ProtoViT. Attention MIL achieves the highest AUROC for tumour (0.74, 95% CI 0.64-0.83) and cyst (0.80, 0.70-0.88), with attention enriched 7.5-9.8x over chance within annotated lesions. The prototype head does not transfer to cyst detection (AUROC 0.51), exposing an interpretability-performance trade-off at this token scale.

Comments: Accepted at MIUA 2026 (poster). To appear in Frontiers in Medical Technology

Subjects:

Computer Vision and Pattern Recognition (cs.CV)

Cite as: arXiv:2607.22687 [cs.CV]

(or arXiv:2607.22687v1 [cs.CV] for this version)

https://doi.org/10.48550/arXiv.2607.22687

arXiv-issued DOI via DataCite (pending registration)

Submission history

From: Sahil Sharma Dr. [view email] [v1] Thu, 16 Jul 2026 14:50:22 UTC (326 KB)

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Key points and analysis

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Key points

  • DINOv3 features from natural images transfer to medical imaging without domain pre-training.
  • Gated attention MIL outperforms CLS linear probe and prototype head for renal tumour and cyst detection.
  • Attention MIL achieves AUROC 0.74 for tumour and 0.80 for cyst, with attention concentrated on lesions.
  • Prototype head fails on cysts (AUROC 0.51), indicating interpretability-performance trade-off.

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